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Research Projects
Our Current Focus
Cause and consequence of somatic mosaicism in aging and cancer
1) AI-guided modeling of epigenetic determinant of genome instability
2) Single-cell Nucleosome Atlas
3) Driver pathways of clonal expansion
in cancer relapse after treatment
Multi-omics integration to improve clinical diagnosis and treatment
1) T cell heterogeneity
(Collaborator : Prof. Je-Min Choi)
2) Cellular heterogeneity in liver diseases (Collaborator : Prof. Dae Won Jun)
3) Multi-omics analysis of PDAC initiation (Collaborator : Prof. Boyoun Park)
4) T cell clone expansion in disease
Bioinformatics model and pipeline development to integrate
bulk/single-cell/spatial omics data
1) AI/ML to infer SV breakpoint from single-cell epigenome
2) AI/ML based inference of gene expression from nucleosome occupancy
3) AI-guided cell type annotation
4) Multi-omics analysis to dissect
gene regulatory network in plants
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