PI profile

Research interests:

• Systems Biology of somatic mosaicism in aging and cancer

• Computational tool development for Single-cell multi-omics

• Disease marker discovery using multi-omics integration

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Future research plan: Single-cell multi-omics to dissect genome-epigenome interaction

• Dissection of epigenetic substructure of tumor and their impact on DNA instability

• Investigation of local chromatin environment which triggers genetic rearrangement

• AI-based modeling of gene expression and their perturbation caused by somatic mutations

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Selected Publications

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• Seung Kyun Noh*, Minhyeok Lee*, and Hyobin Jeong# "Recent advances in single-cell bioinformatics for inferring higher-order chromatin contact maps", BMB Reports, Mini Review, 2025

• Jae-Won Yoon*, Kyung Min Kim*, Sookyung Cho*, Min-Ji Cho, Seonjun Park, Daehee Hwang, Hye Ryun Kim, Sung Ho Park, Jae-Ho Cho, Hyobin Jeong#, Je-Min Choi#,  “Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease”, Nature Communications, 2025​​

• Leppä A-M*, Grimes K*, Jeong H*, Huang F, Andreades A, Waclawiczek A, Boch T, Jauch A, Renders S, Stelmach P, Müller-Tidow C, Karpova D, Sohn M, Grünschläger F, Hasenfeld P, Garagorri E, Thiel V, Dolnik A, Rodriguez-Martin B, Bullinger L, Mrózek K, Eisfeld A-K, Krämer A, Sanders AD, Korbel JO#, Trumpp A#, “Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype”, Nature Genetics, 2024​

• Grimes K*, Jeong H*, Amoah A, Xu N, Niemann J, Raeder B, Hasenfeld P, Stober C, Rausch T, Benito E, Jann J-C, Nowak D, Emini R, Hoenicka M, Liebold A, Ho A, Shui S, Geiger H, Sanders AD#, Korbel JO#, “Cell type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells”, Nature Genetics, 2024

• Jeong H*, Grimes K*, Rauwolf K, Bruch PM, Rausch T, Hasenfeld P, Garagorri E, Roider T, Sabarinathan R, Porubsky D, Herbst S, Erarslan-Uysal B, Jann J-C, Marschall T, Nowak D, Bourquin J-P, Kulozik A, Dietrich S, Bornhauser B, Sanders AD, Korbel JO, "Functional analysis of structural variants in single cells using Strand-seq", Nature Biotechnology, 2023